Early T cell response in the central nervous system in canine distemper virus infection
Identifieur interne : 001948 ( Main/Exploration ); précédent : 001947; suivant : 001949Early T cell response in the central nervous system in canine distemper virus infection
Auteurs : A. Tipold ; P. Moore [États-Unis] ; A. Zurbriggen ; I. Burgener ; G. Barben ; M. VandeveldeSource :
- Acta Neuropathologica [ 0001-6322 ] ; 1999-01-01.
English descriptors
Abstract
Abstract: The initial demyelinating lesions in canine distemper virus (CDV) infection develop during a period of severe immunosuppression in the absence of inflammation. In vitro and in vivo studies suggest that early demyelination is due to directly virus-induced oligodendroglial changes. In the present spatiotemporal study in experimentally CDV-infected dogs we observed diffuse up-regulation of T cells throughout the central nervous system (CNS) and T cell invasion in early demyelinating lesions. Invasion of T cells in the CNS occurred despite severe immunosuppression and without any perivascular cuffing. However, the major fraction of invading T cells correlated with sites of viral replication and coincided with the demonstration of an early immune response against the nucleocapsid protein of CDV. Activation of microglial cells was thought to have elicited the migration of T cells to the CNS by secretion of chemokines: marked IL-8 activity was found in the CSF of dogs with acute lesions. In areas of early demyelination, large numbers of CD3+ cells accumulated in the tissue in the absence of any morphological sign of inflammation. Whether the T cells at lesion sites contribute to the development of acute demyelination remains uncertain at this stage. Antiviral cytotoxicity was not apparent since viral clearance in demyelinating lesions is only effective when B cells and concurring antiviral antibody production appeared in the subacute and chronic inflammatory stage of the disease. CD3+ cells appear to persist for several weeks after infection since they were also found in recovered dogs that did not develop demyelination. Accumulation of immune cells, including a significant proportion of resting T cells (CD45RA+) in the CNS in the early stages of the disease may facilitate the later development of the intrathecal immune response and associated immunopathological complications.
Url:
DOI: 10.1007/s004010050954
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000716
- to stream Istex, to step Curation: 000683
- to stream Istex, to step Checkpoint: 000376
- to stream Main, to step Merge: 001961
- to stream Main, to step Curation: 001948
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Early T cell response in the central nervous system in canine distemper virus infection</title><author><name sortKey="Tipold, A" sort="Tipold, A" uniqKey="Tipold A" first="A." last="Tipold">A. Tipold</name></author><author><name sortKey="Moore, P" sort="Moore, P" uniqKey="Moore P" first="P." last="Moore">P. Moore</name></author><author><name sortKey="Zurbriggen, A" sort="Zurbriggen, A" uniqKey="Zurbriggen A" first="A." last="Zurbriggen">A. Zurbriggen</name></author><author><name sortKey="Burgener, I" sort="Burgener, I" uniqKey="Burgener I" first="I." last="Burgener">I. Burgener</name></author><author><name sortKey="Barben, G" sort="Barben, G" uniqKey="Barben G" first="G." last="Barben">G. Barben</name></author><author><name sortKey="Vandevelde, M" sort="Vandevelde, M" uniqKey="Vandevelde M" first="M." last="Vandevelde">M. Vandevelde</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5B99EFE778144504A5E364C352A09E4B0F4CF1BB</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1007/s004010050954</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-5SBSLK4N-5/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000716</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000716</idno><idno type="wicri:Area/Istex/Curation">000683</idno><idno type="wicri:Area/Istex/Checkpoint">000376</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000376</idno><idno type="wicri:doubleKey">0001-6322:1999:Tipold A:early:t:cell</idno><idno type="wicri:Area/Main/Merge">001961</idno><idno type="wicri:Area/Main/Curation">001948</idno><idno type="wicri:Area/Main/Exploration">001948</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Early T cell response in the central nervous system in canine distemper virus infection</title><author><name sortKey="Tipold, A" sort="Tipold, A" uniqKey="Tipold A" first="A." last="Tipold">A. Tipold</name><affiliation><wicri:noCountry code="subField">CH</wicri:noCountry></affiliation></author><author><name sortKey="Moore, P" sort="Moore, P" uniqKey="Moore P" first="P." last="Moore">P. Moore</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>VM Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, USA</wicri:regionArea><wicri:noRegion>USA</wicri:noRegion></affiliation></author><author><name sortKey="Zurbriggen, A" sort="Zurbriggen, A" uniqKey="Zurbriggen A" first="A." last="Zurbriggen">A. Zurbriggen</name><affiliation><wicri:noCountry code="subField">CH</wicri:noCountry></affiliation></author><author><name sortKey="Burgener, I" sort="Burgener, I" uniqKey="Burgener I" first="I." last="Burgener">I. Burgener</name><affiliation><wicri:noCountry code="subField">CH</wicri:noCountry></affiliation></author><author><name sortKey="Barben, G" sort="Barben, G" uniqKey="Barben G" first="G." last="Barben">G. Barben</name><affiliation><wicri:noCountry code="subField">CH</wicri:noCountry></affiliation></author><author><name sortKey="Vandevelde, M" sort="Vandevelde, M" uniqKey="Vandevelde M" first="M." last="Vandevelde">M. Vandevelde</name><affiliation><wicri:noCountry code="subField">CH</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neuropathologica</title><title level="j" type="abbrev">Acta Neuropathol</title><idno type="ISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1999-01-01">1999-01-01</date><biblScope unit="volume">97</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="45">45</biblScope><biblScope unit="page" to="56">56</biblScope></imprint><idno type="ISSN">0001-6322</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6322</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute demyelination</term><term>Immunosuppression</term><term>Key words Canine distemper virus</term><term>T cells</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The initial demyelinating lesions in canine distemper virus (CDV) infection develop during a period of severe immunosuppression in the absence of inflammation. In vitro and in vivo studies suggest that early demyelination is due to directly virus-induced oligodendroglial changes. In the present spatiotemporal study in experimentally CDV-infected dogs we observed diffuse up-regulation of T cells throughout the central nervous system (CNS) and T cell invasion in early demyelinating lesions. Invasion of T cells in the CNS occurred despite severe immunosuppression and without any perivascular cuffing. However, the major fraction of invading T cells correlated with sites of viral replication and coincided with the demonstration of an early immune response against the nucleocapsid protein of CDV. Activation of microglial cells was thought to have elicited the migration of T cells to the CNS by secretion of chemokines: marked IL-8 activity was found in the CSF of dogs with acute lesions. In areas of early demyelination, large numbers of CD3+ cells accumulated in the tissue in the absence of any morphological sign of inflammation. Whether the T cells at lesion sites contribute to the development of acute demyelination remains uncertain at this stage. Antiviral cytotoxicity was not apparent since viral clearance in demyelinating lesions is only effective when B cells and concurring antiviral antibody production appeared in the subacute and chronic inflammatory stage of the disease. CD3+ cells appear to persist for several weeks after infection since they were also found in recovered dogs that did not develop demyelination. Accumulation of immune cells, including a significant proportion of resting T cells (CD45RA+) in the CNS in the early stages of the disease may facilitate the later development of the intrathecal immune response and associated immunopathological complications.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Barben, G" sort="Barben, G" uniqKey="Barben G" first="G." last="Barben">G. Barben</name><name sortKey="Burgener, I" sort="Burgener, I" uniqKey="Burgener I" first="I." last="Burgener">I. Burgener</name><name sortKey="Tipold, A" sort="Tipold, A" uniqKey="Tipold A" first="A." last="Tipold">A. Tipold</name><name sortKey="Vandevelde, M" sort="Vandevelde, M" uniqKey="Vandevelde M" first="M." last="Vandevelde">M. Vandevelde</name><name sortKey="Zurbriggen, A" sort="Zurbriggen, A" uniqKey="Zurbriggen A" first="A." last="Zurbriggen">A. Zurbriggen</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Moore, P" sort="Moore, P" uniqKey="Moore P" first="P." last="Moore">P. Moore</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001948 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001948 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:5B99EFE778144504A5E364C352A09E4B0F4CF1BB
|texte= Early T cell response in the central nervous system in canine distemper virus infection
}}
| This area was generated with Dilib version V0.6.33. |  |